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WIN-48098-6 Pravadoline

WIN-48098-6 Pravadoline 92623-83-1
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Chemical Information
Product name:WIN-48098-6 Pravadoline Purity:99% min
CAS NO:92623-83-1 Solubility:Soluble in DMSO
Molecular Formula:C23H26N2O3 Package:Package according to customer requirements
Molecular Weight:378.464 Storage:Store at -20℃
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Remarks
Pravadoline, also known as WIN 48098-6, is a agonist of the cannabinoid receptor. Pravadoline inhibited the synthesis of prostaglandins (PGs) in mouse brain both in vitro (IC50, 4.9 microM) and ex vivo (ED50, 20 mg/kg p.o.) and displayed antinociceptive activity in rodents subjected to a variety of chemical, thermal and mechanical nociceptive stimuli.

Properties:
Density 1.18g/cm3

Boiling Point 553.1ºC at 760mmHg
Flash Point 288.3ºC
Refractive Index 1.603
References

1: Everett RM, Descotes G, Rollin M, Greener Y, Bradford JC, Benziger DP, Ward SJ. Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced acute tubular necrosis. Fundam Appl Toxicol. 1993 Jul;21(1):59-65. PubMed PMID: 8365586.

2: D'Ambra TE, Estep KG, Bell MR, Eissenstat MA, Josef KA, Ward SJ, Haycock DA, Baizman ER, Casiano FM, Beglin NC, et al. Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J Med Chem. 1992 Jan;35(1):124-35. PubMed PMID: 1732519.

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