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KC7F2

KC7F2 927822-86-4
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Chemical Information
Product name:KC7F2 Purity:98% min
CAS NO:927822-86-4 Solubility:DMSO : ≥ 32 mg/mL (56.10 mM)
Molecular Formula:C16H16Cl4N2O4S4 Package:Package according to customer requirements
Molecular Weight:570.381 Storage:Store at -20℃
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Remarks
KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis.
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