IVA337 Lanifibranor

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Chemical Information

Product name：IVA337 Lanifibranor	Purity：99% min
CAS NO：927961-18-0	Solubility：DMSO : 100 mg/mL (229.93 mM)
Molecular Formula：C₁₉H₁₅ClN₂O₄S₂	Package：Package according to customer requirements
Molecular Weight：434.916	Storage：Store at -20℃

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Remarks

Lanifibranor is a pan peroxisome proliferator-activated receptor (PPAR) agonist with EC₅₀s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively.

References

[1]. Boubia B, et al. Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J Med Chem. 2018 Feb 27.

[2]. Ruzehaji N, et al. Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.