PPQ-102

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Chemical Information

Product name：PPQ-102	Purity：98% min
CAS NO：931706-15-9	Solubility：DMSO : ≥ 52 mg/mL (118.59 mM)
Molecular Formula：C₂₆H₂₂N₄O₃	Package：Package according to customer requirements
Molecular Weight：438.478	Storage：Store at -20℃

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Remarks

PPQ-102 is a potent and selective CFTR inhibitor. PPQ-102, completely inhibited CFTR chloride current with IC(50) approximately 90 nM. Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state. PPQ-102 prevented cyst expansion and reduced the size of preformed cysts in a neonatal kidney organ culture model of polycystic kidney disease. PPQ-102 is the most potent CFTR inhibitor identified to date.

Synonyms:

7.9-Dimethylxanthin;

7,9-dimethoxy-5H-pyrido<3,2-c>azepine;

7,9-dimethylxanthine;

7,9-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium betaine;

7,9-dimethoxy-5H-pyrido<3,2-c>-azephine;

CFTR Inhibitors Related Prodcuts:

IOWH-032; Ataluren; Lumacaftor; Ivacaftor

References

[1]. Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.

[2]. Stewart AK, et al. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug;301(2):C289-303.