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Product :

BIX-01294

BIX-01294 935693-62-2
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Chemical Information
Product name:BIX-01294 Purity:98% min
CAS NO:935693-62-2 Solubility:DMSO : ≥ 110 mg/mL (224.20 mM)
Molecular Formula:C28H43Cl3N6O3 Package:Package according to customer requirements.
Molecular Weight:618.038 Storage:store at 2-8°C
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Remarks

BIX-01294 is a reversible and highly selective G9a Histone Methyltransferase inhibitor, with an IC50 of 2.7 μM in DELFIA assay. BIX-01294 specifically inhibits G9a (H3K9me2) and GLP enzyme (H3K9me3), with IC50s of 1.7 μM and 38 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

 

Properties:

Boiling point: 654.6±65.0 °C(Predicted)

density: 1.195±0.06 g/cm3(Predicted)

pka: 9.34±0.70(Predicted)

form: Off-white solid

 

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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