Product :
SF1126 Semafore
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Chemical Information
| Product name：SF1126 Semafore |
Purity：98% min |
| CAS NO：936487-67-1 |
Solubility：Soluble in DMSO, not in water |
| Molecular Formula：C41H52N8O16 |
Package：Package according to customer requirements |
| Molecular Weight：912.896 |
Storage：Store at -20℃ |
Remarks
SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK.