FIPI

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Chemical Information

Product name：FIPI	Purity：99% min
CAS NO：939055-18-2	Solubility：DMSO : 14.67 mg/mL (34.81 mM)
Molecular Formula：C₂₃H₂₄FN₅O₂	Package：Package according to customer requirements
Molecular Weight：421.467	Storage：Store at -20℃

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Remarks

FIPI is a potent and selective phospholipase D inhibitor. FIPI attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. FIPI rapidly blocks in vivo PA production with subnanomolar potency. FIPI may be a potential therapeutic for autoimmunity and cancer metastasis.

References

[1]. Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1.

[2]. Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46.