SB-743921 HCl

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Chemical Information

Product name：SB-743921 HCl	Purity：98% min
CAS NO：940929-33-9	Solubility：DMSO : ≥ 100 mg/mL (180.66 mM)
Molecular Formula：C₃₁H₃₄Cl₂N₂O₃	Package：Package according to customer requirements
Molecular Weight：553.519	Storage：Store at -20℃

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Remarks

SB-743921 is a synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis.

References

[1]. Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.

[2]. Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20.