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ML365

ML365 947914-18-3
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Chemical Information
Product name:ML365 Purity:98% min
CAS NO:947914-18-3 Solubility:DMSO : ≥ 100 mg/mL (277.46 mM)
Molecular Formula:C22H20N2O3 Package:Package according to customer requirements
Molecular Weight:360.406 Storage:Store at -20℃
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Remarks

ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.


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