Eflornithine hydrochloride

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Chemical Information

Product name：Eflornithine hydrochloride	Purity：98% min
CAS NO：96020-91-6	Solubility：H2O : ≥ 57 mg/mL (240.87 mM)
Molecular Formula：C₆H₁₅ClF₂N₂O₃	Package：Package according to customer requirements
Molecular Weight：236.645	Storage： Store at -20℃

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Remarks

Eflornithine, also known as Difluoromethylornithine, is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells.

Properties:
Appearance & Physical State: white solid
Density: 1.293g/cm3
Melting Point: >210ºC (dec.)
Boiling Point: 347ºC at 760mmHg
Flash Point: 163.7ºC

References

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.

[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.

[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.