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Reboxetine mesylate is an antidepressant compound that selectively inhibits norepinephrine uptake for norepinephrine and serotonin transporters. Reboxetine mesylate is a potent and selective inhibitor of SLC6A2 noradrenalin uptake. Reboxetine displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine, and muscarinic ACh receptors.