Gimeracil Gimestat

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Gimeracil Gimestat	Purity：98% min
CAS NO：103766-25-2	Solubility：DMSO : 29 mg/mL (199.26 mM)
Molecular Formula：C₅H₄ClNO₂	Package：Package according to customer requirements
Molecular Weight：145.544	Storage：Store at -20℃

Quality control

Remarks

Gimeracil is a pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Properties:
Density: 1.56 g/cm3
Melting Point: 274ºC
Boiling Point: 281.9ºC at 760 mmHg
Flash Point: 124.3ºC
Refractive Index: 1.617
Vapor Pressure: 0.000408mmHg at 25°C

Dehydrogenase Inhibitors Related Products:

Mycophenolate mofetil; AGI-5198; SW033291; Vidofludimus; AGI-6780; Devimistat (CPI-613); Mycophenolic acid; Trilostane; Tenovin-1; Teriflunomide; AG-636; AG-120 (racemic); Ivosidenib ; Brequinar

References

[1]. Sakata K, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep;102(9):1712-6.

[2]. Takagi M, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96(2):259-66.