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Ivosidenib AG-120 racemic

Ivosidenib AG-120 racemic 1448346-63-1
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Chemical Information
Product name:Ivosidenib AG-120 racemic Purity:98% min
CAS NO:1448346-63-1 Solubility:
Molecular Formula:C28H22ClF3N6O3 Package:Package according to customer requirements
Molecular Weight:582.961 Storage:Store at -20℃
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Remarks

AG-120 (racemic), a racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.

 

 

 

Dehydrogenase Inhibitors Related Products:

Mycophenolate mofetil; AGI-5198; SW033291; Vidofludimus; AGI-6780; Devimistat (CPI-613); Mycophenolic acid; Trilostane; Tenovin-1; Teriflunomide; Gimeracil; AG-636; Ivosidenib; Brequinar

References

[1] M Cecilia Caino, Dario C Altieri. Clin Cancer Res. 2016 Feb 1


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