AG-120 (racemic), a racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Dehydrogenase Inhibitors Related Products:
Mycophenolate mofetil; AGI-5198; SW033291; Vidofludimus; AGI-6780; Devimistat (CPI-613); Mycophenolic acid; Trilostane; Tenovin-1; Teriflunomide; Gimeracil; AG-636; Ivosidenib; Brequinar