Ascomycin (FK520)

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Chemical Information

Product name：Ascomycin (FK520)	Purity：98% min
CAS NO：104987-12-4	Solubility：DMSO: ≥ 39 mg/mL
Molecular Formula：C₄₃H₆₉NO₁₂	Package：Package according to customer requirements
Molecular Weight：792.01	Storage：Store at -20℃

Quality control

COA

Remarks

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein.

Properties:

Appearance & Physical State: White Solid

Density: 1.19 g/cm3

Boiling Point: 868.3ºC at 760 mmHg

Melting Point: 153-157ºC

Flash Point: 478.9ºC

Refractive Index: 1.543

Anti-infection Inhibitors Related Prodcuts:

Sulfathiazole sodium; Sulfathiazole; Tofacitinib citrate; Phthalylsulfathiazole; Olsalazine Sodium; Sulfamethoxypyridazine; Buparvaquone ; Sulbactam

References

[1]. Hatanaka H, Kino T, Miyata S, FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601.

[2]. Teutsch M, Higer M, Wang D, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. Int Immunol. 1995 Mar;7(3):381-92.

[3]. Mollison KW, Fey TA, Krause RA, Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998 Feb 6;125(2-3):169-81.