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Dolutegravir sodium salt

Dolutegravir sodium salt 1051375-19-9
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Chemical Information
Product name:Dolutegravir sodium salt Purity:98% min
CAS NO:1051375-19-9 Solubility:DMSO : ≥ 4.5 mg/mL (10.20 mM)
Molecular Formula:C20H18F2N3NaO5 Package:Package according to customer requirements
Molecular Weight:441.361 Storage:Store at -20℃
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Remarks
The EC50 of Dolutegravir (S/GSK1349572) against HIV-1 is 0.51 nM in PBMCs, 0.71 nM in MT-4 cells, and 2.2 nM in the PHIV assay, which uses a pseudotyped self-inactivating virus. The 50% cytotoxic concentrations (CC50) for Dolutegravir in proliferating IM-9, U-937, MT-4, and Molt-4 cells are 4.8, 7.0, 14, and 15 μM, respectively. In unstimulated and stimulated PBMCs, the CC50 are 189 μM and 52 μM, respectively. Based on the EC50 of Dolutegravir against HIV-1 in PBMCs (i.e., 0.51 nM), this translates to a cell-based therapeutic index of at least 9,400.
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