Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.
Chemical Properties:
Boiling point: 840.6±65.0 °C(Predicted)
density: 1.21
pka: 13.65±0.40(Predicted)
IAP Inhibitors Related Products:
AT-406 HCl; Birinapant; ASTX660