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AT406 (SM-406)

AT406 (SM-406) 1071992-99-8
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Chemical Information
Product name:AT406 (SM-406) Purity:98% min
CAS NO:1071992-99-8 Solubility:100 mg/mL (178.02 mM)
Molecular Formula:C32H43N5O4 Package:Packaging according to customer requirements
Molecular Weight:561.71 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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Remarks
DeBio-1143, also known as AT-406, ARRY-334543and SM-406, is an orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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