Birinapant TL32711

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Chemical Information

Product name：Birinapant TL32711	Purity：98% min
CAS NO：1260251-31-7	Solubility：DMSO : ≥ 40 mg/mL (49.57 mM)
Molecular Formula：C₄₂H₅₅F₂N₇O₆	Package：Package according to customer requirements
Molecular Weight：791.926	Storage：Store at -20℃

Quality control

COA

Remarks

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2.

IAP Inhibitors Related Products:

AT-406 HCl; ASTX660; Xevinapant (AT406)

References

[1]. Allensworth JL, et al. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. Breast Cancer Res Treat. 2013 Jan;137(2):359-71.

[2]. Krepler C, et al. The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells. Clin Cancer Res. 2013 Apr 1;19(7):1784-94.