CNX-774

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Chemical Information

Product name：CNX-774	Purity：98% min
CAS NO：1202759-32-7	Solubility：DMSO : ≥ 45 mg/mL (90.09 mM)
Molecular Formula：C₂₆H₂₂FN₇O₃	Package：Package according to customer requirements
Molecular Weight：499.496	Storage：Store at -20℃

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Remarks

CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.

BTK inhibitor Related Prodcuts:

Ibrutinib; Spebrutinib; Remibrutinib; Evobrutinib; Acalabrutinib; Olmutinib; ONO-4059 analog; RN486; CGI-1746; Zanubrutinib

References

[1]. Akinleye A, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol. 2013 Aug 19;6:59.

[2]. In Vitro Reactivity Assessment of Covalent Drugs Targeting Bruton's Tyrosine Kinase