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ATB-346

ATB-346 1226895-20-0
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Chemical Information
Product name:ATB-346 Purity:98% min
CAS NO:1226895-20-0 Solubility:DMSO : ≥ 51.6 mg/mL (141.20 mM)
Molecular Formula:C19H21Cl2N3 Package:Package according to customer requirements
Molecular Weight:365.445 Storage:Store at -20℃
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Remarks

ATB-346 is anti- inflammatory agent, which is structurally an analogue of naproxen. ABT-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. ATB-346 suppressed colonic prostaglandin synthesis and whole blood thromboxane synthesis as effectively as naproxen, but did not induce any gastrointestinal injury. ATB-346 exerts superior chemopreventive effects to those of naproxen, while sparing the gastrointestinal tract of the injury normally associated with use of the parent drug. ATB-346 may therefore be an attractive agent for chemoprevention of colon cancer, and possibly of cancers in other tissues.

 

 

 

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