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VE-822 Berzosertib

VE-822 Berzosertib 1232416-25-9
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Chemical Information
Product name:VE-822 Berzosertib Purity:98% min
CAS NO:1232416-25-9 Solubility:DMSO : ≥ 35 mg/mL (75.50 mM)
Molecular Formula:C24H25N5O3S Package:Package according to customer requirements
Molecular Weight:463.552 Storage:Store at -20℃
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Berzosertib, also known as M6620, VE-822, VX-970, is an potent ATR inhibitor. VE-822 inhibited ATR in vitro and in vivo. VE-822 decreased maintenance of cell-cycle checkpoints, increased persistent DNA damage and decreased homologous recombination in irradiated cancer cells. VE-822 decreased survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine. VE-822 markedly prolonged growth delay of pancreatic cancer xenografts after XRT and gemcitabine-based chemoradiation without augmenting normal cell or tissue toxicity. These findings support ATR inhibition as a promising new approach to improve the therapeutic ration of radiochemotherapy for patients with PDAC.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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