M344

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Chemical Information

Product name：M344	Purity：98% min
CAS NO：251456-60-7	Solubility：DMSO : ≥ 100 mg/mL (325.32 mM)
Molecular Formula：C₁₆H₂₅N₃O₃	Package：Package according to customer requirements
Molecular Weight：307.388	Storage：Store at -20℃

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Remarks

M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.

Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.

Properties:
Density: 1.137g/cm3
Refractive Index: 1.558

Related Prodcuts:

Fidaxomicin; Marbofloxacin; CP-466722; TTP 22; D-64131; CHIR-124; Reversine; Pralatrexate; XL228; VE-822; RI-1; SRPIN340; XL888; Rigosertib; APY29; NMS-873; PF-03758309; Telatinib

References

[1]. Jung M1, et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42(22):4669-79.

[2]. Weberpals JI, et al. The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11(1):29.