Venetoclax ABT-199

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Chemical Information

Product name：Venetoclax ABT-199	Purity：98% min
CAS NO：1257044-40-8	Solubility：DMSO : 77.5 mg/mL (89.24 mM)
Molecular Formula：C₄₅H₅₀ClN₇O₇S	Package：Package according to customer requirements
Molecular Weight：868.439	Storage：Store at -20℃

Quality control

COA

Remarks

Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.

Bcl-2 Inhibitors Related Products:

ABT-737; Obatoclax Mesylate; HA14-1; S63845; UMI-77; Mifepristone; Navitoclax

References

[1]. Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.

[2]. Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47.

[3]. Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764.