Pixantrone

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Chemical Information

Product name：Pixantrone	Purity：98% min
CAS NO：144510-96-3	Solubility：H2O : < 0.1 mg/mL (insoluble)
Molecular Formula：C₁₇H₁₉N₅O₂	Package：Package according to customer requirements
Molecular Weight：325.365	Storage：Store at -20℃

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Remarks

Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Pixantrone is a potentially more effective, less cardiotoxic alternative to doxorubicin for patients with aggressive non-Hodgkin lymphoma (aNHL).

Related Products:

Vinorelbine Tartrate; Vinblastine sulfate; Vinflunine; NU7441; Volasertib; TAK-901; Cidofovir; Cidofovir dihydrate; Pixantrone dimaleate; Fludarabine; Fludarabine Phosphate; Clofarabine; Nelarabine; Vorinostat

References

[1]. Beeharry N, et al. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015;16(9):1397-406.

[2]. Hasinoff BB, et al. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409.