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Fludarabine Phosphate

Fludarabine Phosphate 75607-67-9
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Chemical Information
Product name:Fludarabine Phosphate Purity:98% min
CAS NO:75607-67-9 Solubility:DMSO : ≥ 100 mg/mL (273.82 mM)
Molecular Formula:C10H13FN5O7P Package:Packaging according to customer requirements
Molecular Weight:365.21 Storage:Store at -20℃
Quality control
COA
Remarks

Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

 

Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner. Fludarabine Phosphate competes with dATP for incorporation into the A site of the extending DNA strand, which results in termination of DNA strand elongation. Human DNA polymerase α incorporates more Fludarabine Phosphate into DNA than polymerase δ. Fludarabine Phosphate completively inhibits DNA polymerase α and DNA polymerase δ with Ki of 1.1 μM and 1.3 μM, respectively. DNA polymerase δ is also able to excise the incorporated Fludarabine Phosphate from DNA in vitro. 

 

Properties:

Density : 2.39 g/cm3

Boiling Point: 864.2ºC at 760 mmHg

Flash Point: 476.4ºC

Refractive Index: 1.878

 

Related Prodcuts: 

Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Nelarabine; Cladribine; Trifluridine; Daptomycin; Vorinostat

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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