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Fludarabine Phosphate

Fludarabine Phosphate 75607-67-9
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Chemical Information
Product name:Fludarabine Phosphate Purity:98%min
CAS NO:75607-67-9 Solubility:Soluble in DMSO
Molecular Formula:C10H13FN5O7P Package:Packaging according to customer requirements
Molecular Weight:365.21 Storage:Store at -20℃
Quality control
COA
Remarks

Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner. Fludarabine Phosphate competes with dATP for incorporation into the A site of the extending DNA strand, which results in termination of DNA strand elongation. Human DNA polymerase α incorporates more Fludarabine Phosphate into DNA than polymerase δ. Fludarabine Phosphate completively inhibits DNA polymerase α and DNA polymerase δ with Ki of 1.1 μM and 1.3 μM, respectively. DNA polymerase δ is also able to excise the incorporated Fludarabine Phosphate from DNA in vitro. [1]

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