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Trifluridine

Trifluridine 70-00-8
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Chemical Information
Product name:Trifluridine Purity:98%min
CAS NO:70-00-8 Solubility:Soluble in DMSO
Molecular Formula:C10H11F3N2O5 Package:Packaging according to customer requirements
Molecular Weight:296.20 Storage:Store at -20℃
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Remarks

Trifluridine is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently. Trifluridine inhibits colony formation of bone marrow cells in a concentration-dependent manner. [1] Trifluridine (FTD) and 2'-deoxy-5-fluorouridine (FdUrd) are incorporated into DNA with different efficiencies due to differences in the substrate specificities of TK1 and DUT, causing abundant FTD incorporation into DNA. FTD-treated cells shows differing nuclear morphologies compared to FdUrd-treated cells. [2] Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently. [3]

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