5-Trifluorothymidine Trifluridine

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Chemical Information

Product name：5-Trifluorothymidine Trifluridine	Purity：98% min
CAS NO：70-00-8	Solubility：DMSO : ≥ 100 mg/mL (337.61 mM)
Molecular Formula：C₁₀H₁₁F₃N₂O₅	Package：Package according to customer requirements
Molecular Weight：296.200	Storage：Store at -20℃

Quality control

COA

Remarks

Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. It is a component of the experimental anti-cancer drug TAS-102.

Properties:

Appearance & Physical State: white crystalline powder

Density: 1.646g/cm3

Melting Point: 190-193ºC

Refractive Index: 1.534

Related Prodcuts:

Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Fludarabine Phosphate; Nelarabine; Cladribine; Daptomycin

References

[1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70.

[2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397.