Temozolomide (CCRG81045, NSC 362856, TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity..
Properties:
Appearance & Physical State: Off-White to Light-Pink Crystalline Solid
Density: 1.97 g/cm3
Boiling Point: 526.6ºC at 760 mmHg
Melting Point: 210-212ºC
Flash Point: 272.3ºC
Related Prodcuts:
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