ETC-206

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：ETC-206	Purity：98% min
CAS NO：1464151-33-4	Solubility：DMSO : ≥ 50 mg/mL (122.41 mM)
Molecular Formula：C₂₅H₂₀N₄O₂	Package：Package according to customer requirements.
Molecular Weight：408.452	Storage：-20 ℃

Quality control

Remarks

ETC-206 is a selective MNK1/2 inhibitor with IC50 = 64 nM (for MNK1) and IC50 = 84 nM (for MNK2). ETC-206 in combination with dasatinib prevents BC-CML LSC self-renewal in vitro and enhances dasatinib antitumor activity in vivo.

Chemical Name:

4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile

MNK inhibitor Related Products:

Tomivosertib

References

[1]. Yang H, et al. Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. J Med Chem. 2018 May 24;61(10):4348-4369.