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tomivosertib eFT508

tomivosertib eFT508 1849590-01-7
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Chemical Information
Product name:tomivosertib eFT508 Purity:98% min
CAS NO:1849590-01-7 Solubility:Soluble in DMSO
Molecular Formula:C17H20N6O2 Package:Package according to customer requirements
Molecular Weight:340.38 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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Remarks
eFT508 has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. Treatment of tumor cell lines with eFT508 leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50 = 2-16 nM). In a panel of ~50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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