Tomivosertib (eFT-508)

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Chemical Information

Product name：Tomivosertib (eFT-508)	Purity：98% min
CAS NO：1849590-01-7	Solubility：DMSO : 4.35 mg/mL (12.78 mM)
Molecular Formula：C₁₇H₂₀N₆O₂	Package：Package according to customer requirements
Molecular Weight：340.38	Storage：Store at -20℃

Quality control

Remarks

Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.

Properties:

Boiling point: 735.6±60.0 °C(Predicted)

density: 1.43±0.1 g/cm3(Predicted)

pka: 13.77±0.60(Predicted)

MNK inhibitor Related Products:

ETC-206

References

[1]. Kevin R. Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL). Blood 2015 126:1554;