PF06447475

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Chemical Information

Product name：PF06447475	Purity：99% min
CAS NO：1527473-33-1	Solubility：DMSO: ≥ 33 mg/mL
Molecular Formula：C₁₇H₁₅N₅O	Package：Package according to customer requirements
Molecular Weight：305.334	Storage：Store at -20℃

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Remarks

PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD.

Chemical Properties:

density: 1.40±0.1 g/cm3(Predicted)

form: powder

pka: 12.96±0.50(Predicted)

color: white to beige

LRRK2 Inhibitors Related Products:

GSK2578215A; GNE-0877; URMC-099; LRRK2-IN-1

References

[1]. Henderson JL, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

[2]. Mendivil-Perez M, et al. Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease. Neurochem Res. 2016 Oct;41(10):2675-2692.