GSK3787

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Chemical Information

Product name：GSK3787	Purity：98% min
CAS NO：188591-46-0	Solubility：DMSO : ≥ 50 mg/mL (127.30 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₁₅H₁₂ClF₃N₂O₃S	Package：Package according to customer requirements
Molecular Weight：392.781	Storage：Store at -20℃

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Remarks

GSK-3787 is a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist with good pharmacokinetic properties. GSK3787 can antagonize PPARbeta/delta in vivo, thus providing a new strategy to delineate the functional role of a receptor with great potential as a therapeutic target for the treatment and prevention of disease.

PPAR Inhibitors Related Prodcuts:

GW9662; Fenofibric acid; Bezafibrate

References

[1]. Shearer BG, et al. Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J Med Chem. 2010 Feb 25;53(4):1857-61.

[2]. Palkar PS, et al. Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol. 2010 Sep;78(3):419-30.