JIB-04

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Chemical Information

Product name：JIB-04	Purity：98% min
CAS NO：199596-05-9	Solubility：DMSO : 22.5 mg/mL (72.87 mM)
Molecular Formula：C₁₇H₁₃ClN₄	Package：Package according to customer requirements
Molecular Weight：308.765	Storage：Store at -20℃

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Remarks

JIB-04, also known as NSC 693627, is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.

Histone Demethylase Inhibitors Related Products:

OG-L002; Z-JIB-04; GSK-J1

References

[1]. Wang L, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 2013. 4: p. 2035.

[2]. Banelli B, et al. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget. 2017 Apr 4.