Z-JIB-04

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Chemical Information

Product name：Z-JIB-04	Purity：98% min
CAS NO：199596-24-2	Solubility：DMSO : 6 mg/mL (19.43 mM; Need ultrasonic)
Molecular Formula：C₁₇H₁₃ClN₄	Package：Package according to customer requirements
Molecular Weight：308.765	Storage：Store at -20℃

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Remarks

JIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.

Histone Demethylase Inhibitors Related Products:

OG-L002; JIB-04; GSK-J1

References

1: Van Rechem C, Black JC, Boukhali M, Aryee MJ, Graslund S, Haas W, Benes CH, Whetstine JR. Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis. Cancer Discov. 2015 Jan 6. pii: CD-14-1326. [Epub ahead of print] PubMed PMID: 25564516.

2: Sekar TV, Foygel K, Gelovani JG, Paulmurugan R. Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals. Anal Chem. 2014 Dec 24. [Epub ahead of print] PubMed PMID: 25506787.