Brefeldin A

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Chemical Information

Product name：Brefeldin A	Purity：98% min
CAS NO：20350-15-6	Solubility：DMSO : 20.83 mg/mL (74.30 mM)
Molecular Formula：C₁₆H₂₄O₄	Package：Package according to customer requirements
Molecular Weight：280.359	Storage：Store at -20℃

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Remarks

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.

Properties:

Appearance & Physical State: White solid

Density: 1.108 g/cm3

Boiling Point: 492.7ºC at 760 mmHg

Melting Point: 200-205ºC

Flash Point: 87ºC

Refractive Index: 1.513

Antibiotics Inhibitors Related Products:

Idarubicin HCl; Fumagillin; Pleuromutilin; Retapamulin

References

[1]. Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14.

[2]. Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9.