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Micafungin sodium

Micafungin sodium 208538-73-2
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Chemical Information
Product name:Micafungin sodium Purity:98%min
CAS NO:208538-73-2 Solubility:Soluble in DMSO
Molecular Formula:C56H70N9NaO23S Package:Packaging according to customer requirements
Molecular Weight:1292.26 Storage:Store at -20℃
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Remarks

Micafungin (sodium) is an inhibitor of 1, 3-beta-D-glucan synthesis, and used as an antifungal drug.

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts[1]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone[2].

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals[2].

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