Degarelix

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Chemical Information

Product name：Degarelix	Purity：98% min
CAS NO：214766-78-6	Solubility：DMSO : 10 mg/mL (6.13 mM)
Molecular Formula：C₈₂H₁₀₃ClN₁₈O₁₆	Package：Package according to customer requirements
Molecular Weight：1632.26	Storage：-20℃

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Remarks

Degarelix, also known as FE-200486 and ASP-3550, is a long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.

Related Products:

Plecanatide; Linaclotide; Carbetocin; Octreotide acetate; Terlipressin; Cetrorelix; Desmopressin; Desmopressin acetate; Goserelin acetate; Ganirelix Acetate; Abarelix; GLP-1 (7-37); Semaglutide

References

[1]. Rick FG, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402.

[2]. Sakai M, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonistdegarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10(3):e0120670.

[3]. Broqua P, et al. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormoneantagonist: degarelix. J Pharmacol Exp Ther. 2002 Apr;301(1):95-102.