MCC950 CP-456773 sodium

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Chemical Information

Product name：MCC950 CP-456773 sodium	Purity：98% min
CAS NO：256373-96-3	Solubility：DMSO : 50 mg/mL (117.24 mM)
Molecular Formula：C₂₀H₂₃N₂NaO₅S	Package：Package according to customer requirements.
Molecular Weight：426.462	Storage：Store at -20℃

Quality control

COA

Remarks

MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

Synonyms:

CRID3 sodiumsalt;

MCC950(CP-456773) sodium;

CP-456773 sodium;

MCC950 (CP-456773) sodium;

sodium salt of 1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]-urea;

NLRP3 Inhibitors Related Products:

Dapansutrile

References

[1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.

[2]. Zhai Y, et al. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018 Feb 27;23(3). pii: E522.