Dapansutrile, also known as OLT1177, is an anti-inflammatory, analgesic drug candidate. Dapansutrile is a β-sulfonyl nitrile inhibitor of the NLRP3 inflammasome that inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A. murine macrophages, human monocyte derived macrophages (HMDMs), and primary human blood neutrophils without affecting TNF-α release.
Synonyms:
1-cyano-2-methylisoindole;
3-methanesulfonylpropionitrile;
2-methyl-2H-isoindole-1-carbonitrile;
2H-Isoindole-1-carbonitrile,2-methyl;
3-(methylsulfonyl)propionitrile;
1-cyano-2-methylsulphonylethane;
NLRP3 Inhibitors Related Products:
MCC950 Sodium