A286982

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Chemical Information

Product name：A286982	Purity：98% min
CAS NO：280749-17-9	Solubility：DMSO: soluble10mg/mL, clear
Molecular Formula：C₂₄H₂₇N₃O₄S	Package：Package according to customer requirements
Molecular Weight：453.55	Storage：-20℃

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Remarks

A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.

Integrin Related Products:

Cilengitide; Lifitegrast; Leukadherin 1; Vedolizumab; Cilengitide trifluoroacetate; Eptifibatide

References

[1]. G Liu, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Med Chem. 2000 Oct 19;43(21):4025-40.

[2]. Susan M Keating, et al. Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. Protein Sci. 2006 Feb;15(2):290-303.