Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.
Properties:
Boiling point: 634.7±65.0 °C(Predicted)
density: 1.50±0.1 g/cm3(Predicted)
form: powder
pka: 4.11±0.10(Predicted)
color: yellow to orange to brown
Integrin Related Products:
Cilengitide; Lifitegrast; Vedolizumab; Cilengitide trifluoroacetate; Eptifibatide; A286982