Allopurinol

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Chemical Information

Product name：Allopurinol	Purity：99% min
CAS NO：315-30-0	Solubility：DMSO : 14 mg/mL (102.86 mM)
Molecular Formula：C₅H₄N₄O	Package：Package according to customer requirements
Molecular Weight：136.111	Storage：Store at -20℃

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Remarks

Allopurinol is a structural isomer of hypoxanthine. Allopurinol inhibits the enzyme xanthine oxidase, which converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, which provvides protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies.

Properties:
Appearance & Physical State: White to Off-White Solid
Density: 1.89g/cm3
Melting Point: 350ºC
Boiling Point: 290.8ºC at 760 mmHg
Flash Point: 129.7ºC
Refractive Index: 1.816
Water Solubility: 0.35 g/L (25 ºC)

Xanthine Oxidase Related Products:

Febuxostat; Topiroxostat

References

[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

[2]. Reiter S, et al. Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol. Clin Chim Acta. 1990 Mar 15;187(3):221-34.