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C646 328968-36-1
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Chemical Information
Product name:C646 Purity:98% min
CAS NO:328968-36-1 Solubility:DMSO : ≥ 36 mg/mL (80.82 mM)
Molecular Formula:C24H19N3O6 Package:Package according to customer requirements
Molecular Weight:445.424 Storage:Store at -20℃
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C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
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