Erythromycin estolate

Erythromycin estolate is a macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Properties:
Appearance & Physical State: Long needles
Melting Point: 135-140ºC dec.
Boiling Point: 827.7ºC at 760 mmHg
Flash Point: 454.4ºC

Bacterial inhibitor Related Products:

Rifamycin sodium salt; Rifamycin; Moxifloxacin; Moxifloxacin HCL; Cefoperazone sodium; Erythromycin Ethylsuccinate; Ceftezole; Ceftriaxone Sodium; Sulfacetamide sodium salt hydrate; Sulfachloropyridazine; Sulfachloropyridazine Sodium; Florfenicol; Furagin; Latamoxef sodium; Nimorazole; Ciprofloxacin hydrochloride hydrate; Ciprofloxacin; Cefoxitin Sodium; Azelaic acid

1: Lu X, Tian Y, Lian X, Jin Y, Jin T, Zhao Q, Hu B, Shen X, Fan X. Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat. Food Chem Toxicol. 2014 Mar;65:343-55. doi: 10.1016/j.fct.2013.12.050. Epub 2014 Jan 10. PubMed PMID: 24412560.

2: Lakritz J, Wilson WD, Marsh AE, Mihalyi JE. Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Am J Vet Res. 2000 Aug;61(8):914-9. PubMed PMID: 10951982.