GS-7340 Tenofovir alafenamide

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Chemical Information

Product name：GS-7340 Tenofovir alafenamide	Purity：99% min
CAS NO：379270-37-8	Solubility：DMSO : ≥ 31 mg/mL (65.06 mM); H2O : 6.67 mg/mL (14.00 mM)
Molecular Formula：C₂₁H₂₉N₆O₅P	Package：Package according to customer requirements
Molecular Weight：476.466	Storage：Store at -20℃

Quality control

COA| NMR

Remarks

Tenofovir alafenamide, also known as TAF and GS-7340, is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevent HIV from multiplying and can reduce the amount of HIV in the body. Tenofovir alafenamide is a prodrug, which means that it is an inactive drug. In the body, tenofovir alafenamide is converted to tenofovir diphosphate (TFV-DP). Tenofovir alafenamide fumarate was approved in November 2015 for treatment of HIV-1.

Related Prodcuts:

Tenofovir Disoproxil Fumarate; Tenofovir; Tenofovir alafenamide fumarate

References

[1]. Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.

[2]. Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.