Tenofovir alafenamide fumarate

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Chemical Information

Product name：Tenofovir alafenamide fumarate	Purity：99.0% min
CAS NO：379270-38-9	Solubility：DMSO : ≥ 36 mg/mL (60.76 mM);H2O : ≥ 25 mg/mL (42.19 mM)
Molecular Formula：C₂₅H₃₃N₆O₉P	Package：Package according to customer requirements
Molecular Weight：592.538	Storage：Store at -20℃

Quality control

COA

Remarks

Tenofovir alafenamide, also known as TAF and GS-7340, is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevent HIV from multiplying and can reduce the amount of HIV in the body. Tenofovir alafenamide is a prodrug, which means that it is an inactive drug. In the body, tenofovir alafenamide is converted to tenofovir diphosphate (TFV-DP). Tenofovir alafenamide fumarate was approved in November 2015 for treatment of HIV-1.

Related Prodcuts:

Tenofovir Disoproxil Fumarate; Tenofovir alafenamide; Tenofovir

References

[1]. Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.

[2]. Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.