Clemizole

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Clemizole	Purity：98% min
CAS NO：442-52-4	Solubility：Soluble in DMSO
Molecular Formula：C₁₉H₂₀ClN₃	Package：Package according to customer requirements
Molecular Weight：325.835	Storage：Store at -20℃

Quality control

Remarks

Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC₅₀ of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC₅₀ for viral replication is 8 µM.

Properties:
Density: 1.25g/cm3
Boiling Point: 506.1ºC at 760mmHg
Flash Point: 259.9ºC
Refractive Index: 1.655
Vapor Pressure: 2.29E-10mmHg at 25°C

TRP Channel Inhibitors Related Products:

AMG9810; TRPM8 Antagonist 2; SB366791; Rosiglitazone; HC-030031; Clemizole hydrochloride; AMG-517

References

[1]. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27

[2]. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21