Eltrombopag

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Chemical Information

Product name：Eltrombopag	Purity：98% min
CAS NO：496775-61-2	Solubility：DMSO: 14 mg/mL
Molecular Formula：C₂₅H₂₂N₄O₄	Package：Package according to customer requirements
Molecular Weight：442.467	Storage：Store at -20℃

Quality control

COA

Remarks

Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.

Chemical Properties:

Melting point: 242-244°C

Boiling point: 656.8±65.0 °C(Predicted)

density: 1.33

pka: -1.26±0.40(Predicted)

TpoR Agonists Related Products:

Eltrombopag Olamine

References

[1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.

[2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93.

[3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36.