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Eltrombopag Olamine

Eltrombopag Olamine 496775-62-3
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Chemical Information
Product name:Eltrombopag Olamine Purity:98% min
CAS NO:496775-62-3 Solubility:10 mM in DMSO
Molecular Formula:C29H36N6O6 Package:Package according to customer requirements
Molecular Weight:564.633 Storage:Store at -20℃
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Eltrombopag, also known as SB-497115-GR, is an agonist of the c-mpl (TpoR) receptor, which is the physiological target of the hormone thrombopoietin. Eltrombopag was initially approved by in 2008, for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglobulin therapy, or splenectomy. In preclinical studies, Eltrombopag was shown to interact selectively with the thrombopoietin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes.
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