Turofexorate isopropyl

Turofexorate isopropyl, also known as WAY-362450 and XL335, is a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR) (EC(50) = 4 nM, Eff = 149%), which attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.

Synonyms:

WAY-362450;

3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid isopropyl ester;

FXR-450;

isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate;

propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate;

XL335;

Properties:

Density: 1.275

Boiling Point: 617.283ºC at 760 mmHg

Flash Point: 327.121ºC

Refractive Index: 1.6

FXR Agonists Related Products:

T0901317; Obeticholic Acid; Tropifexor

[1]. Flatt B, et al. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J Med Chem. 2009 Feb 26;52(4):904-7.

[2]. Evans MJ, et al. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G543-52.