INT-747 Obeticholic Acid

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Chemical Information

Product name：INT-747 Obeticholic Acid	Purity：98% min
CAS NO：459789-99-2	Solubility：DMSO : ≥ 100 mg/mL (237.74 mM)
Molecular Formula：C₂₆H₄₄O₄	Package：Package according to customer requirements.
Molecular Weight：420.625	Storage：Store at -20℃

Quality control

COA

Remarks

Obeticholic Acid (INT747; 6-ECDCA) is a novel derivative of cholic acid which acts as a potent and selective FXR agonist displaying anticholeretic activity in an in vivo rat model of cholestasis. It inhibits vascular smooth muscle cell inflammation and migration as well as promotes adipocyte differentiation and regulates adipose cell function in vivo.

Properties:

Density: 1.091

Boiling Point: 562.9ºC at 760 mmHg

Flash Point: 308.3ºC

Refractive Index: 1.529

FXR Agonists Related Products:

Turofexorate isopropyl; T0901317; Tropifexor

References

[1]. Fiorucci S, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther. 2005 May;313(2):604-12.

[2]. Ghebremariam YT, et al. FXR agonist INT-747 upregulates DDAH expression and enhances sensitivity in high-salt fed Dahl rats. PLoS One. 2013 Apr 4;8(4):e60653.