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Product :

Nilotinib

Nilotinib 641571-10-0
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Chemical Information
Product name:Nilotinib Purity:98% min
CAS NO:641571-10-0 Solubility:DMSO: 35 mg/mL (66.09 mM)
Molecular Formula:C28H22F3N7O Package:Package according to customer requirements.
Molecular Weight:529.5272 Storage:Store at -20℃
Quality control
COA
Remarks

Nilotinib, also known as AMN107, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10-30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells. Nolitinib was developed by Novartis and is sold under the trade name Tasigna.

 

 

 

Related Products:  

Nilotinib hcl monohydrate; Nilotinib intermediate

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