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Nilotinib 641571-10-0
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Chemical Information
Product name:Nilotinib Purity:98% min
CAS NO:641571-10-0 Solubility:Soluble in DMSO, not in water
Molecular Formula:C28H22F3N7O Package:Package according to customer requirements
Molecular Weight:529.5272 Storage:Store at -20℃
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Nilotinib, also known as AMN107, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10-30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells. Nolitinib was developed by Novartis and is sold under the trade name Tasigna.

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